Infertile Men at Risk for Diabetes, Osteoporosis?

Men with low sperm counts have higher odds of getting a metabolic disease like diabetes or osteoporosis in later years, a new study says.

Metabolism refers to the chemical reactions in your body's cells that let you get or use energy from things like food. Metabolic diseases interfere with that process.

The study looks into whether infertility, in men under 50 years old, could help doctors predict whether they'll get such diseases down the road. The research appears in the journal Clinical Endocrinology.

About 15% of all couples contend with infertility, and about half the time, it's due to the man being infertile. Past studies have shown an unexplained link between men with poor semen quality and a lower life expectancy.

"There is a significant need for more studies in this field," says University of Copenhagen Professor Jens Sønksen in a statement from the European Association of Urology 2016 Congress in Munich, where the new research was presented.


Low Sperm Counts

It’s unclear to what degree young men with fertility problems have signs of low testosterone levels (also called "hypogonadism"), say Johannes Bobjer, of Skåne University Hospital and Lund University in Sweden, and colleagues. It’s also not clear whether low T is linked to a risk for osteoporosis and metabolic problems, as it is in older men.

To examine this issue, researchers studied 192 men ages 18 to 50 with a low sperm count, and compared them with an age-matched group of 199 other men.

They compared sex hormone levels and other signs, such as bone mineral density and blood sugar levels.

Low testosterone levels were 10 times higher among the men with fertility problems than among those in the control group.

A third of men with fertility problems and low T were found to also have higher blood sugar levels and lower bone mineral density in the lumbar spine compared to those with normal testosterone levels.

Men with low T also had higher triglycerides (a type of fat found in the blood), signs of insulin resistance, and an increased risk of metabolic syndrome, compared to men with fertility problems but hormone levels in the normal range.


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